What Really Causes Obesity?
There is no doubt that obesity is on the rise. But why? Is it because we are not exercising enough? Or are we simply overeating? Obviously,…
The Science of the Zone
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Why Metabolic Engineering?
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It Starts With The Zone Diet
30 Years of The Zone
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Live Your Life To The Fullest In The Zone
Wellness is a lifelong commitment. It begins in the womb and goes through the continuum of life. The…
What Is The Zone?
The Zone is the physiological state when your metabolism performs at peak efficiency. Metabolism keeps us alive by…
Benefits Of Being In The Zone
The health benefits of being in the Zone are numerous. Here is a small listing of those benefits: AMPK…
Evolution Of The Zone
For the past 40 years, I have been exploring the mysteries of metabolism and how diet can control…
GLP-1 Drugs
JAMA on GLP-1 Drugs—Here’s Dr. Sears’ Take
The Journal of the American Medical Association recently published an article on tips for using GLP-1 drugs (1). …
What Is AMPK?
Defining Anti-Inflammatory Diets
To make science reproducible, you must have definitions. The more rigorous the description, the more likely the science…
Insulin Resistance
Insulin Resistance and Weight Loss
Carbohydrates are often villainized as the culprit for our weight gain, but it’s more complex than this. It is…
Stages of Life
In-Vitro Fertilization
The ProblemConsidering the complex metabolic changes that are required to take place in successful conception, it is not…
More on Metabolism
How AMPK Activation Can Help Prevent Long COVID-19
It has been nearly five years since COVID-19 first appeared. However, for many, the consequences of initial infection remain with them for years. About 7 percent…
Can Epigenetic Clocks Predict Your Biological Age?
There are two types of age: chronological and biological. Chronological age is simple—it’s the date on your birthdate. Biological age is trickier since it depends on how…
Want To Live Longer? Try Following Metabolic Engineering®.
Calorie restriction is the only proven way to extend lifespan. More importantly, it is also the best way to extend your healthspan, which is defined as…
GLP-1 Drugs & Heart Health: Beyond The Hype
Drug companies are far better marketers than developers of new medical breakthroughs. Terms like “revolutionary”, “game-changer”, or “medical breakthrough” are used as standard practice, especially since…
Ask Dr. Sears: Is There A Sugar I Can Eat To Lose Weight?
Surprisingly, the answer is yes. It is a natural sugar called allulose. It has 70% of the sweetness of table sugar, but a completely different metabolic…
Is A Leaky Gut Caused By Inhibition of AMPK?
People are obsessed with gut health. They should be, because without a healthy gut, you would be a sitting target for continual bacterial invasion from the…
The Wellness Zone Episodes
Welcome to The Wellness Zone Podcast hub, where Zone Diet creator Dr. Barry Sears and Mary Perry help you decode the science behind your health. Each…
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Wellness Zone Podcast
JAMA on GLP-1 Drugs—Here’s Dr. Sears’ Take
The Journal of the American Medical Association recently published an article on tips for using GLP-1 drugs (1). Are these tips valid? Let’s find out? First,…
Stopping GLP-1 Drugs May Increase Cardiovascular Risk
Everyone wants to lose excess body fat. However, the Holy Grail of weight loss is losing excess body fat while maintaining, if not increasing, lean body…
