CV

Barry Sears, Ph.D. Curriculum Vitae

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Address: 200 Corporate Place, Suite 7, Peabody, MA 01960

Date of Birth: June 6, 1947

Place of Birth: Long Beach, CA

Research Interests: Dietary modulation of hormonal responses and eicosanoid biosynthesis; use of anti-inflammatory nutrition for the treatment of chronic-disease conditions.

Education:

  • 1964-1968 A.B. (with Honors) Occidental College
  • 1968-1971 Ph.D. Indiana University

Postdoctoral Training:

  • 1971-1974 University of Virginia Medical School, Department of Biochemistry
  • 1974-1975 Boston University Medical School, Department of Medicine

Academic and Non-Profit Positions:1975-1978 research instructor, Department of Medicine, Boston University Medical School

  • 1978-1982 staff scientist, National Magnet Laboratory, Massachusetts Institute of Technology
  • 2003-present president, Inflammation Research Foundation, Peabody, MA

Industrial Positions:

  • 1976-1986 President, Lipid Specialties, Inc.
  • 1982-1986 President, PGE Technologies, Inc.
  • 1986-1992 President, BIOSYN, Inc.
  • 1992-1996 President, Eicotec Foods, Inc.
  • 1992-present President, Surfactant Technologies, Inc.
  • 1996-1999 President, Eicotech Corporation
  • 1999-present President, Zone Labs, Inc.
  • 2006-present President, MedWell Foods, Inc.

Publications

  1. Griffiths, R.R., Sears, B., and Jennings, L.B. “Specificity of transfer of a learned response by intracisternal injection of brain extract from trained rats: negative findings.” Psychological Reports 25: 339-348 (1969)
  2. Baumrucker, J., Calzadilla, M., Centeno, M., Lehrmann, G., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. “Secondary valence force catalysis. XI. Enhanced reactivity and affinity of cyanide ions elicted by ionic surfactants.” J Phys Chem 74: 1152-1156 (1970)
  3. Baumrucker, J., Calzadilla, M., Centeno, M, Lehrmann, G., Urdaneta, M., Linquist, P., Dunham, D., Price, M., Sears, B., and Cordes, E.H. “Secondary valence force catalysis. XII. Enhanced reactivity and affinity of cyanide toward N-substituted 3- carbomoyl-pyridinium ions elicted by ionic surfactants and biological lipids.” J Am Chem Soc 94: 8162-8172 (1972)
  4. Williams, E., Sears, B., Allerhand, A., and Cordes, E.H. “Segmental motion of amphipathic molecules in aqueous solutions and micelles. Applications of natural abundance 13C partially relaxed fourier transform nuclear magnetic resonance spectroscopy. J Am Chem Soc 95: 4871-4874 (1973)
  5. Sears, B., Hutton, W.C., and Thompson, T.E. “13C NMR studies on bilayers formed from synthetic di-10-methyl-stearoyl phosphatidylcholine enriched with 13C in the N- methyl carbons.” Biochem Biophys Res Comm 60: 1141-147 (1974)
  6. Sears, B. “13C nuclear magnetic resonance studies of egg phosphatidylcholine.” J Mem Biol 20: 59-73 (1975)
  7. Sears, B., Hutton, W.C., and Thompson, T.E. “Effects of paramagnetic shift reagents on the 13C nuclear magnetic resonance spectra of egg phosphatidylcholine enriched with 13C in the N-methyl carbons.” Biochemistry 15: 1635-1639 (1976).
  8. Yeagle, P.E., Hutton, W.C., Martin, R.B., Sears, B., and Huang. C. “Transmembrane asymmetry of vesicle lipids.” J Biol Chem 251: 2110-2114 (1976) 9. Sears, B., Deckelbaum, R.J., Janiak, M.J., Shipley, G.G., and Small, D.M. “Temperature dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins.” Biochemistry 15: 4151-4157 (1976)
  9. Sears, B., Deckelbaum, R.J., Janiak, M.J., Shipley, G.G., and Small, D.M. “Temperature dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins.” Biochemistry 15: 4151-4157 (1976)
  10. Curatolo, W.C., Shipley, G.G., Small, D.M., Sears, B., and Neuringer, L.J. “Effect of lectin-induced agglutination on 13C nuclear magnetic resonance line width in sonicated phospholipid/glycolipid vesicles.” J Amer Chem Soc 99: 6771-6772 (1977)
  11. Roseman, M.A., Lentz, B., Sears, B., Gibbes, D., and Thompson, T.E. “Properties of sonicated vesicles of three synthetic phospholipids.” Chem Phys Lipids 21: 205-210 (1978)
  12. Curatolo, W.C., Yau, A.O., Small, D.M., and Sears, B. “Lectin-induced agglutination of phospholipid/glycolipid vesicles.” Biochemistry 17: 5740-5744 (1978)
  13. Neuringer, L.J., Sears, B., and Jungalwala. “Difference in orientational order in phospholipid and sphingomyelin bilayers. FEBS Letters 104: 173-175 (1979)
  14. Neuringer, L.J., Sears, B., and Jungalwala, F.B. “2H NMR studies of the interaction of cerebrosides with dipalmitoyl phosphatidylcholine in bilayers.” Biochim Biophys Acta 558: 325-329 (1979)
  15. Widder, K.J., Senyei, A.E. and Sears, B. “Experimental methods in cancer therapeutics.” J Pharm Sci 71: 379-387 (1982)
  16. Mendelsohn, R., Dluhy, R.A., Curatolo, and Sears, B. “Order and fluidity in terminal methyl regions of dipalmitoyl phosphatidylcholine mutilayers: a comparison of Raman and deuterium NMR spectroscopy.” Chem Phys Lipids 30: 287-291 (1983)
  17. Stark, R.E., Manstein, J.L., Curatolo, W.C., and Sears, B. “Deuterium NMR of bile salt/phosphatidylcholine mixed micelles.” Biochemistry 22: 2486-2490 (1983)
  18. Curatolo, W.C., Sears, B., and Neuringer, L.J. “A calorimetry and deuterium NMR study of mixed model membranes of 1-palmitoyl-2-oleyl phosphatidylcholine and saturated phosphatidylcholines.” Biochim Biophys Acta 817: 261-270 (1985)
  19. Curatolo, W.C., Jungalwala, F.B., Sears, B., Tuck, L., and Neuringer, L.J. “Deuterium NMR spectroscopy of biosynthetically deuterated mammalian tissues.” Biochemistry 24: 4360-4364 (1985)
  20. Sears, B. “Essential fatty acids and dietary endocrinology: a hypothesis for cardiovascular treatment.” J Adv Med 6: 211-224 (1993)
  21. Sears, B. “The Zone diet and athletic performance.” Sports Med 99: 289-291 (2000)
  22. Bell, S.J. and Sears, B. “Low-glycemic load diets: Impact on obesity and chronic diseases.” Crit Rev Food Sci and Nutr 43: 357-377 (2003)
  23. Bell SJ and Sears B. “A Proposal for a New National Diet: A Low Glycemic- Load Diet with a Unique Macronutrient Composition.” Metabol Synd and Related Disord 1:199-208 (2003).
  24. Bell SJ and Sears B. “The Zone Diet: An Anti-Inflammatory, Low Glycemic-Load Diet.” Metabol Synd and Related Disord 2:24-38 (2004).
  25. Johnston CS, Tjonn S, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low- carbohydrate diets.” Am J Clin Nutr 83: 1055-1061 (2006)
  26. Johnston CS, Tjonn SL, Swan PD, White A, and Sears B. “Low-carbohydrate, high- protein diets that restrict potassium-rich fruits and vegetables promote calciuria.” Osteoporos Int 17: 1820-1821 (2006)
  27. Johnston, CS, White AM, Tjonn, S, Swan PD, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low- carbohydrate diets. Reply to NJ Krilanovich.” Am J Clin Nutr 85: 239 (2007)
  28. Sorgi PJ, Hallowell EM, Hutchins HL, and Sears B. “Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder Nutr J 13:16 (2007)
  29. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B. “Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: A pilot study.” J Am Diet Assoc 107: 1792-1796 (2007)
  30. Sears B. “Anti-inflammatory diets for obesity and diabetes.” J Coll Amer Nutr 28: 482S-491S (2009)
  31. Mills JD, Bailes JE, Sedney CL, Hutchins H, and Sears B. “Omega-3 dietary supplementation reduces traumatic axonal injury in a rodent head injury model”. J Neurosurgery 114: 77-84 (2011)
  32. Sears B and Ricordi C. “Anti-inflammatory nutrition as a pharmacological approach to treat obesity.” J Obesity 2011: 431985 (2011)
  33. Sears B and Ricordi C. “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.” Eur Rev Med Pharmacol Sci 16: 1137-1154 (2012)
  34. Lotrich, FE, Sears, B, and McNamara RK. “Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon- alpha treatment: Relationship with interleukin-6.” Brain, Behavior, and Immunity 31: 48-53 (2013)
  35. Sears B, Bailes J, and Asselin B. “Therapeutic uses of high-dose omega-3 fatty acids to treat comatose patients with severe brain injury.” PharmaNutrition 1: 86-89 (2013)
  36. Lotrich FE, Sears B, and McNamara R.K. “Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.” J Psychosomatic Res 75:475-483 (2013)
  37. McNamara RK, Perry M, and Sears, B. “Dissociation of C-reactive protein levels from long-chain omega-3 fatty acid status and anti-depressant response in adolescents with major depressive disorder: an open-label dose-ranging trial.” J Nutr Therapeutics 2:235-243 (2013)
  38. Georgiou T, Neokleous A, Nikolaou D, and Sears B. “Pilot study for treating dry age-related macular degeneration (AMD) with high-dose omega-3 fatty acids.” PharmaNutrition 2:8-11 (2014)

Books

  1. Sears, B. The Zone. Regan Books (Harper Collins). New York, NY. (1995)
  2. Sears, B. Mastering the Zone. Regan Books (Harper Collins). New York, NY (1997)
  3. Sears, B. Zone Perfect Meals in Minutes. Regan Books (Harper Collins). New York, NY (1997)
  4. Sears, B. Zone Food Blocks. Regan Books (Harper Collins). New York, NY (1998)
  5. Sears, B. The Anti-Aging Zone. Regan Books (Harper Collins). New York, NY (1999)
  6. Sears, B. A Week in the Zone. Regan Books (Harper Collins). New York, NY (2000)
  7. Sears, B. The Soy Zone. Regan Books (Harper Collins). New York, NY (2000)
  8. Sears, B. 100 Great Zone Foods. Regan Books (Harper Collins). New York, NY (2001)
  9. Sears B. The OmegaRx Zone. Regan Books (Harper Collins). New York, NY (2002)
  10. Sears B. What to Eat in the Zone. Regan Books (Harper Collins). New York, NY (2003)
  11. Sears, B. and Sears, L. Zone Meals in Seconds. Regan Books (Harper Collins). New York, NY (2004)
  12. Sears, B. The Anti-Inflammation Zone. Regan Books (Harper Collins). New York, NY (2005)
  13. Sears, B. Toxic Fat. Thomas Nelson, Nashville, TN (2008)
  14. Sears B. The Mediterranean Zone. Zink (Random House) (2014)

U.S. Patents

  1. Sears, B. “Phosphatidyl quarternary ammonium compounds.” U.S. Patent No. 4,086,257 (1978)
  2. Sears, B. “Phosphatidyl sulfonium compounds.” U.S. Patent No. 4,097,502 (1978)
  3. Sears, B. “Phosphatidyl phosphonium compounds.” U.S. Patent No. 4,097,503 (1978)
  4. Sears, B. “Method for determining the level of LDL cholesterol in blood plasma.” U.S. Patent No. 4,126,416 (1978)
  5. Sears, B. “Method of preparing a controlled release pharmaceutical preparation.” U.S. Patent No. 4,145,410 (1979)
  6. Sears, B. “Kit for determining the level of LDL cholesterol in body fluids.” U.S. Patent No. 4,190,628 (1980)
  7. Sears, B. and Yesair, D.W. “Xenobiotic delivery vehicles.” U.S. Patent No. 4,298,594 (1981)
  8. Sears, B. “Method of emulsifying cholesterol, cholesterol esters, and triglyceride compounds.” U.S. Patent No. 4,320,121 (1982)
  9. Sears, B. “Synthetic phospholipid compounds.” U.S. Patent No. 4,426,330 (1984)
  10. Sears, B. “Magnetic compositions and magnetic memory devices prepared.” U.S. Patent No. 4,507,217 (1985)
  11. Sears, B. “Synthetic phospholipid compounds.” U.S. Patent No. 4,534,899 (1985)
  12. Sears, B. “Method for reducing blood pressure levels in hypertensive persons.” U.S. Patent No. 5,059,622 (1991)
  13. Sears, B. “Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia.” U.S. Patent No. 6,140,304 (2000)
  14. Sears, B. “Novel inhibitors of arachidonic acid formation.”  U.S. Patent No. 8,987,325 (2015)

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