CV

Barry Sears, Ph.D. Curriculum Vitae

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Address:                     200 Corporate Place, Peabody MA 01960

Date of Birth:             June 6, 1947

Place of Birth:            Long Beach, CA

 

Research Interests:   Dietary modulation of hormonal responses and eicosanoid biosynthesis, use of anti-inflammatory nutrition for the treatment of chronic disease conditions.

 

Education:

 

  • 1964-1968        A.B. (with Honors) Occidental College
  • 1968-1971        Ph.D. Indiana University

 

Postdoctoral Training:

 

  • 1971-1974       University of Virginia Medical School, Department of Biochemistry
  • 1974-1975       Boston University Medical School, Department of Medicine

 

Academic and Non-Profit Positions:

 

  • 1975-1978       Research Instructor, Department of Medicine, Boston University Medical School

 

  • 1978-1982       Staff Scientist, National Magnet Laboratory, Massachusetts Institute of Technology

 

  • 2003-present   President, Inflammation Research Foundation, Peabody, MA

 

  • 2016-present   Voluntary Assistant Professor of Surgery, University of Miami Medical School

 

  • 2016-present   Adjunct Faculty, School of Nutrition and Health Promotion, College of Health Solutions, Arizona State University

 

Industrial Positions:

 

  • 1976-1986                   President, Lipid Specialties, Inc.
  • 1982-1986                   President, PGE Technologies, Inc.
  • 1986-1992                   President, BIOSYN, Inc.
  • 1992-1996                   President, Eicotec Foods, Inc.
  • 1992-present               President, Surfactant Technologies, Inc.
  • 1996-1999                   President, Eicotech Corporation
  • 1999-present               President, Zone Labs, Inc.
  • 2006-present               President, MedWell Foods, Inc.

 

Professional Memberships:

 

  • American Oil Chemists Society
  • International Society for the Study of Fatty Acids and Lipids
  • American Diabetes Association
  • Obesity Society
  • American Society of Bariatric Physicians

 

Editorial Board Membership:

 

CellR4:  Repair, Replacement, Regeneration, and Reprogramming

 

Publications

 

  1. Griffiths RR, Sears B, and Jennings LB. “Specificity of transfer of a learned response by intracisternal injection of brain extract from trained rats: negative findings.” Psychological Reports 25:339-348 (1969)
  1. Baumrucker J, Calzadilla M, Centeno M, Lehrmann G, Linquist P, Dunham D, Price M, Sears B, and Cordes EH. “Secondary valence force catalysis.  XI.  Enhanced reactivity and affinity of cyanide ions elicted by ionic surfactants.”  J Phys Chem 74:1152-1156 (1970)
  1. Baumrucker J, Calzadilla M, Centeno M, Lehrmann G, Urdaneta M, Linquist P, Dunham D, Price M, Sears B, and Cordes EH. “Secondary valence force catalysis.  XII.  Enhanced reactivity and affinity of cyanide toward N-substituted 3-carbomoyl-pyridinium ions elicted by ionic surfactants and biological lipids.”  J Am Chem Soc 94:8162-8172 (1972)
  1. Williams E, Sears B, Allerhand A, and Cordes EH. “Segmental motion of amphipathic molecules in aqueous solutions and micelles.  Applications of natural abundance 13C partially relaxed fourier transform nuclear magnetic resonance spectroscopy.  J Am Chem Soc 95:4871-4874 (1973)
  1. Sears B, Hutton WC, and Thompson TE. “13C NMR studies on bilayers formed from synthetic di-10-methyl-stearoyl phosphatidylcholine enriched with 13C in the N-methyl carbons.”  Biochem Biophys Res Comm 60:1141-147 (1974)
  1. Sears B. “13C nuclear magnetic resonance studies of egg phosphatidylcholine.”  J Mem Biol 20:59-73 (1975)
  1. Sears B, Hutton WC, and Thompson TE. “Effects of paramagnetic shift reagents on the 13C nuclear magnetic resonance spectra of egg phosphatidylcholine enriched with 13C in the N-methyl carbons.” Biochemistry 15:1635-1639 (1976)
  1. Yeagle PE, Hutton WC, Martin RB, Sears B, and Huang C. “Transmembrane asymmetry of vesicle lipids.”  J Biol Chem 251:2110-2114 (1976)
  1. Sears B, Deckelbaum RJ, Janiak MJ, Shipley GG, and Small DM. “Temperature dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins.”  Biochemistry 15:4151-4157 (1976)
  1. Curatolo WC, Shipley GG, Small DM, Sears B, and Neuringer LJ. “Effect of lectin-induced agglutination on 13C nuclear magnetic resonance line width in sonicated phospholipid/glycolipid vesicles.”  J Amer Chem Soc 99:6771-6772 (1977)
  1. Roseman MA, Lentz B, Sears B, Gibbes D, and Thompson TE. “Properties of sonicated vesicles of three synthetic phospholipids.”  Chem Phys Lipids 21:205-210 (1978)
  1. Curatolo WC, Yau AO, Small DM, and Sears B. “Lectin-induced agglutination of phospholipid/glycolipid vesicles.”  Biochemistry 17:5740-5744 (1978)
  1. Neuringer LJ, Sears B, and Jungalwala FB. “Difference in orientational order in phospholipid and sphingomyelin bilayers.  FEBS Letters 104:173-175 (1979)
  1. Neuringer LJ, Sears B, and Jungalwala FB. “2H NMR studies of the interaction of cerebrosides with dipalmitoyl phosphatidylcholine in bilayers.” Biochim Biophys Acta 558:325-329 (1979)
  1. Widder KJ, Senyei AE, and Sears B. “Experimental methods in cancer therapeutics.”  J Pharm Sci 71:379-387 (1982)
  1. Mendelsohn R, Dluhy RA, Curatolo WC, and Sears B. “Order and fluidity in terminal methyl regions of dipalmitoyl phosphatidylcholine mutilayers:  a comparison of Raman and deuterium NMR spectroscopy.”  Chem Phys Lipids 30:287-291 (1983)
  1. Stark RE, Manstein JL, Curatolo WC, and Sears B. “Deuterium NMR of bile salt/phosphatidylcholine mixed micelles.”  Biochemistry 22:2486-2490 (1983)
  1. Curatolo WC, Sears B, and Neuringer LJ “A calorimetry and deuterium NMR study of mixed model membranes of 1-palmitoyl-2-oleyl phosphatidylcholine and saturated phosphatidylcholines.” Biochim Biophys Acta 817:261-270 (1985)
  1. Curatolo WC, Jungalwala FB, Sears B, Tuck L, and Neuringer LJ. “Deuterium NMR spectroscopy of biosynthetically deuterated mammalian tissues.”  Biochemistry 24:4360-4364 (1985)
  1. Sears B. “Essential fatty acids and dietary endocrinology: a hypothesis for cardiovascular treatment.”  J Adv Med 6:211-224 (1993)
  1. Sears B. “The Zone Diet and athletic performance.”  Sports Med 99:289-291 (2000)
  1. Bell SJ and Sears B. “Low-glycemic load diets: Impact on obesity and chronic diseases.” Crit Rev Food Sci Nutr 43:357-377 (2003)
  1. Bell SJ and Sears B. “A Proposal for a New National Diet:  A Low Glycemic- Load Diet with a Unique Macronutrient Composition.”  Metabol Synd Related Disord 1:199-208  (2003)
  1. Bell SJ and Sears B. “The Zone Diet: An Anti-Inflammatory, Low Glycemic-Load Diet.”  Metabol Synd and Related Disord 2:24-38 (2004)
  1. Johnston CS, Tjonn S, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.” Am J Clin Nutr 83:1055-1061 (2006)
  1. Johnston CS, Tjonn SL, Swan PD, White A, and Sears B. “Low-carbohydrate, high-protein diets that restrict potassium-rich fruits and vegetables promote calciuria.” Osteoporos Int 17:1820-1821 (2006)
  1. Johnston, CS, White AM, Tjonn, S, Swan PD, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Reply to NJ Krilanovich.” Am J Clin Nutr 85:239 (2007)
  1. Sorgi PJ, Hallowell EM, Hutchins HL, and Sears B. “Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder Nutr J 13:16 (2007)
  1. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B. Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: A pilot study.” J Am Diet Assoc 107:1792-1796 (2007)
  1. Sears B. “Anti-inflammatory diets for obesity and diabetes.”  J Coll Amer Nutr 28:482S-491S (2009)
  1. Mills JD, Bailes JE, Sedney CL, Hutchins H, and Sears B. “Omega-3 dietary supplementation reduces traumatic axonal injury in a rodent head injury model”. J Neurosurgery 114:77-84 (2011)
  1. Sears B and Ricordi C. “Anti-inflammatory nutrition as a pharmacological approach to treat obesity.” J Obesity 2011:431985 (2011)
  1. Sears B and Ricordi C. “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.”  Eur Rev Med Pharmacol Sci 16:1137-1154 (2012)
  1. Lotrich, FE, Sears, B, and McNamara RK. “Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6.”  Brain, Behavior, and Immunity 31:48-53 (2013)
  1. Sears B, Bailes J, and Asselin B. “Therapeutic uses of high-dose omega-3 fatty acids to treat comatose patients with severe brain injury.”  PharmaNutrition 1: 86-89 (2013)

 

  1. Lotrich FE, Sears B, and McNamara R.K. “Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.”  J Psychosomatic Res  75:475-483 (2013)
  1. McNamara RK, Perry M, and Sears, B. “Dissociation of C-reactive protein levels from long-chain omega-3 fatty acid status and anti-depressant response in adolescents with major depressive disorder:  an open-label dose-ranging trial.”  J Nutr Therapeutics 2:235-243 (2013)
  1. Georgiou T, Neokleous A, Nikolaou D, and Sears B. “Pilot study for treating dry age-related macular degeneration (AMD) with high-dose omega-3 fatty acids.” PharmaNutrition 2:8-11 (2014)
  1. Sears B and Perry M. “The role of fatty acids in insulin resistance.”  Lipids Health Disease 14:121 (2015)
  1. Sears B. “Anti-inflammatory diets.” J Am Coll Nutr 34: Suppl 1 14-21 (2015)
  1. Lotrich FE, Sears B, and McNamara RK. “Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk.”  Prostaglandins Leukot Essent Fatty Acids 106:19-25 (2016)
  1. Sears B. “High-dose omega-3 fatty acids and vitamin D for preservation of residual beta cell mass in type 1 diabetes.”  CellR4  4:e2107 (2016)
  1. Sears B. “Delaying adverse health consequences of aging:  The role of omega-3 fatty acids on inflammation and resoleomics.”  CellR4  4:e2111 (2016)

 

Books

 

  1. Sears B. The Zone.  Regan Books (Harper Collins). New York, NY  (1995)
  1. Sears B. Mastering the Zone.  Regan Books (Harper Collins).  New York, NY (1997)
  1. Sears B. Zone Perfect Meals in Minutes.  Regan Books (Harper Collins). New York, NY (1997)
  1. Sears B. Zone Food Blocks.  Regan Books (Harper Collins). New York, NY (1998)
  1. Sears B. The Anti-Aging Zone.  Regan Books (Harper Collins). New York, NY (1999)
  1. Sears B. A Week in the Zone.  Regan Books (Harper Collins). New York, NY (2000)
  1. Sears B. The Soy Zone. Regan Books (Harper Collins). New York, NY (2000)
  1. Sears B. 100 Great Zone Foods.  Regan Books (Harper Collins).  New York, NY (2001)
  1. Sears B. The OmegaRx Zone.  Regan Books (Harper Collins).  New York, NY (2002)
  1. Sears B. What to Eat in the Zone.  Regan Books (Harper Collins).  New York, NY (2003)
  1. Sears B and Sears L. Zone Meals in Seconds.  Regan Books (Harper Collins). New York, NY (2004)
  1. Sears B. The Anti-Inflammation Zone. Regan Books (Harper Collins). New York, NY (2005)
  1. Sears B. Toxic Fat.  Thomas Nelson. Nashville, TN (2008)
  1. Sears B. The Mediterranean Zone.  Zink (Ballantine Books).  New York, NY (2014)
  1. Ferrazzi E and Sears B eds. Metabolic Syndrome and Complications of Pregnancy. Springer.  Heidelburg, Germany (2015)

  

U.S. Patents

 

  1. Sears, B.    “Phosphatidyl quarternary ammonium compounds.”  U.S. Patent No. 4,086,257 (1978)
  1. Sears, B. “Phosphatidyl sulfonium compounds.”  U.S. Patent No. 4,097,502 (1978)
  1. Sears, B.    “Phosphatidyl phosphonium compounds.”  U.S. Patent No. 4,097,503 (1978)
  1. Sears, B.    “Method for determining the level of LDL cholesterol in blood plasma.”  U.S. Patent No. 4,126,416 (1978)
  1. Sears, B.    “Method of preparing a controlled release pharmaceutical preparation.” U.S. Patent No. 4,145,410 (1979)
  1. Sears, B.    “Kit for determining the level of LDL cholesterol in body fluids.”  U.S. Patent No. 4,190,628 (1980)
  1. Sears, B. and Yesair, D.W. “Xenobiotic delivery vehicles.” U.S. Patent No. 4,298,594 (1981)
  1. Sears, B. “Method of emulsifying cholesterol, cholesterol esters, and triglyceride compounds.”  U.S. Patent No. 4,320,121 (1982)
  1. Sears, B. “Synthetic phospholipid compounds.” U.S. Patent No. 4,426,330 (1984)
  1. Sears, B. “Magnetic compositions and magnetic memory devices prepared.”  U.S. Patent No. 4,507,217 (1985)
  1. Sears, B. “Synthetic phospholipid compounds.”  U.S. Patent No. 4,534,899 (1985)
  1. Sears, B. “Method for reducing blood pressure levels in hypertensive persons.”  U.S. Patent No. 5,059,622 (1991)
  1. Sears, B. “Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia.”  U.S. Patent No. 6,140,304 (2000)
  1. Sears, B. “Novel inhibitors of arachidonic acid formation.”  U.S. Patent No. 8,987,325 (2015)