High-dose Polyphenols

Polyphenols have dose-dependent effects. At low doses (approximately 0.5 grams per day) they can activate gene transcription factors (such as Nrf2) that increase the synthesis of anti-oxidative enzymes to reduce oxidative stress. At higher levels (approximately 1.0 grams per day) polyphenols activate anti-inflammatory gene transcription factors (such as PPARγ) that inhibit the initiation phase of inflammation. At still higher levels (approximately 1.5 grams per day) polyphenols activate the SIRT1 gene that increases the production of AMP kinase (AMPK) that controls cellular metabolism.