Dr. Barry Sears Dr. Sears Comments:

It was shown 20 years ago (Adams et al. Lipids. 1996 Mar;31 Suppl:S157-61) that the ratio of AA/EPA in the blood was an excellent marker of depression.  The AA/EPA ratio is also an excellent marker for cellular inflammation as well as IL-1. I guess no one reads the scientific literature anymore.

Blood test could tailor treatment for depression

According to a recent study, an analysis of blood samples can highlight high levels of inflammation in a patient and help predict which drugs may not be effective. Other recent studies have found a link between increased inflammation and lower success rates from treatment.

Dr. Barry Sears Dr. Sears Comments:

The linkage of the two conditions is via insulin resistance.  Gestational diabetes is cause by insulin resistance.  One of the consequences of insulin resistance is an increase in cortisol.  Increased cortisol levels increase depression.

Depression During Pregnancy Linked To Gestational Diabetes

Depression during and after pregnancy may be linked to gestational diabetes, a new government study found. Women in the study who reported feeling depressed early in pregnancy were more likely to develop gestational diabetes later in pregnancy compared with those who did not report depression early in pregnancy, according to the study, from researchers at the National Institute of Child Health and Human Development (NICHD).


Dr. Barry Sears Dr. Sears Comments:

Omega-3 fatty acids rich in EPA have been shown to have strong clinical benefits in treating mono- and bipolar depression as well as other neurological conditions such as anxiety and ADHD. But this is only true if you are giving therapeutic doses. A therapeutic dose is one that reduces the AA/EPA ratio in the blood to less than 3. Since the average American has an AA/EPA ratio of approximately 20, this will probably require a minimum of 5 to 7.5 grams of EPA and DHA on a daily basis to have consistent benefits.

Can Supplements Help Fight Depression?

If you take medication for depression but still struggle a bit, adding a daily dose of fish oil or vitamin D just might lift you out of your rut. According to a new meta-analysis from the University of Melbourne in Australia, certain dietary supplements may increase the effectiveness of antidepressants such as Zoloft, Paxil, Pristiq, and Cymbalta.

Dr. Barry Sears Dr. Sears Comments:

It seems like some very weak science stands behind this article.  Bottom line, neither ADHD or depression is good for children.  The one dietary approach that has been demonstrated to treat both is high-dose fish oil (greater than 7.5 grams of EPA and DHA per day).  At those levels, the omega-3 fatty acids increase both dopamine and serotonin in the brain.

More Child Suicides Are Linked to A.D.D. Than Depression, Study Suggests

Attention deficit disorder is the most common mental health diagnosis among children under 12 who die by suicide, a new study has found. Very few children aged 5 to 11 take their own lives, and little is known about these deaths.


Dr. Barry Sears Dr. Sears Comments:

Omega-3 fatty acids, like drugs, work at therapeutic levels.  For mono-polar depression that will be at least 5 grams of EPA and DHA per day, and for bipolar greater than 10 grams of EPA and DHA per day.  The data is also clear that you need both omega-3 fatty acids, not just DHA.  The high doses are required to get adequate levels into the brain to decrease the inflammation that is the underlying cause of depression because increased inflammation disrupts the transmission of neuotransmitter signaling.

Why You Might Want to Start Taking Fish Oil

Finding ways to make antidepressants more effective could help the millions of people who take them for depression. Now early research suggests pairing the medication with certain supplements, including omega-3 fish oil and vitamin D, could be one way to do so.


Dr. Barry Sears Dr. Sears Comments:

Of all the nutrients mentioned, only high-dose EPA has the greatest impact on treating depression in clinical studies.  This explains why the AA/EPA ratio is a powerful predictor of the severity of depression.



Dr. Barry Sears Dr. Sears Comments:

A far better starting approach to get the depressed patient more willing to exercise and practice meditation is supplementation with high-dose EPA and DHA (5-10 grams per day).  That will reduce neuroinflammation in the brain as well as promote increased serotonin production.  When both those events occur, the desire to exercise and practice stress reduction is greatly enhanced.



Dr. Barry Sears Dr. Sears Comments:

It has long been known that high-dose omega-3 fatty acids are very effective in treating depression.  Unlike traditional anti-inflammatory drugs, omega-3 fatty acids can easily pass through the brain-blood-barrier to reduce neuroinflammation.  The secret is having a high enough concentration in the blood.  That is usually achieved if you can maintain an AA/EPA ratio between 1.5 and 3, as do the Japanese who also have the lowest rates of depression in the world.

New research suggests depression is an “inflammation disease,” and can be treated with anti-inflammatory drugs

There is growing evidence that inflammation-already known to be a cause of many whole-body diseases-is also involved in diseases of the brain, including psychiatric conditions like depression. Depression is a common and crippling disease affecting over 350 million people worldwide. Around 20 percent of the U.K.


Dr. Barry Sears Dr. Sears Comments:

The growing increase in teen depression and anxiety matches with similar increases in allergies, chronic fatigue syndrome, irritable bowel syndrome, and autistic spectrum disorders.  There appears to be a growing connection between all of these conditions and a breakdown of the gut barrier resulting in greater neuro-inflammation.

Depression In Teenage Girls Is Worse Than Ever

“Teenage girls today face a huge range of pressures. Stress at school, body image worries, early sexualisation, bullying on and offline and uncertainty about the future after school are all piling on the stress,”Nick Harrop, campaigns manager of British charity YoungMinds, told the Telegraph.”Social media also puts pressure on girls to live their lives in the public domain, to present a personal ‘brand’ from a young age, and to seek reassurance in the form of likes and shares.”