Dr. Barry Sears Dr. Sears Comments:

Omega-3 fatty acids, like drugs, work at therapeutic levels.  For mono-polar depression that will be at least 5 grams of EPA and DHA per day, and for bipolar greater than 10 grams of EPA and DHA per day.  The data is also clear that you need both omega-3 fatty acids, not just DHA.  The high doses are required to get adequate levels into the brain to decrease the inflammation that is the underlying cause of depression because increased inflammation disrupts the transmission of neuotransmitter signaling.

Why You Might Want to Start Taking Fish Oil

Finding ways to make antidepressants more effective could help the millions of people who take them for depression. Now early research suggests pairing the medication with certain supplements, including omega-3 fish oil and vitamin D, could be one way to do so.


Dr. Barry Sears Dr. Sears Comments:

Of all the nutrients mentioned, only high-dose EPA has the greatest impact on treating depression in clinical studies.  This explains why the AA/EPA ratio is a powerful predictor of the severity of depression.



Dr. Barry Sears Dr. Sears Comments:

A far better starting approach to get the depressed patient more willing to exercise and practice meditation is supplementation with high-dose EPA and DHA (5-10 grams per day).  That will reduce neuroinflammation in the brain as well as promote increased serotonin production.  When both those events occur, the desire to exercise and practice stress reduction is greatly enhanced.



Dr. Barry Sears Dr. Sears Comments:

It has long been known that high-dose omega-3 fatty acids are very effective in treating depression.  Unlike traditional anti-inflammatory drugs, omega-3 fatty acids can easily pass through the brain-blood-barrier to reduce neuroinflammation.  The secret is having a high enough concentration in the blood.  That is usually achieved if you can maintain an AA/EPA ratio between 1.5 and 3, as do the Japanese who also have the lowest rates of depression in the world.

New research suggests depression is an “inflammation disease,” and can be treated with anti-inflammatory drugs

There is growing evidence that inflammation-already known to be a cause of many whole-body diseases-is also involved in diseases of the brain, including psychiatric conditions like depression. Depression is a common and crippling disease affecting over 350 million people worldwide. Around 20 percent of the U.K.


Dr. Barry Sears Dr. Sears Comments:

The growing increase in teen depression and anxiety matches with similar increases in allergies, chronic fatigue syndrome, irritable bowel syndrome, and autistic spectrum disorders.  There appears to be a growing connection between all of these conditions and a breakdown of the gut barrier resulting in greater neuro-inflammation.

Depression In Teenage Girls Is Worse Than Ever

“Teenage girls today face a huge range of pressures. Stress at school, body image worries, early sexualisation, bullying on and offline and uncertainty about the future after school are all piling on the stress,”Nick Harrop, campaigns manager of British charity YoungMinds, told the Telegraph.”Social media also puts pressure on girls to live their lives in the public domain, to present a personal ‘brand’ from a young age, and to seek reassurance in the form of likes and shares.”


Dr. Barry Sears Dr. Sears Comments:

There are two factors that have nothing to do with genetics that are more important in developing depression.  One is a deficiency of omega-3 fatty acids (especially EPA). The other is inflammation induced by gut microbes that are directly transmitted to the brain via the vagus nerve to increase neuroinflammation.


New insights into genes affecting depression risk

In a key advance for the study of depression, a comprehensive scan of human DNA has turned up the apparent hiding places of more than a dozen genes linked to the disorder. “This is a jumping-off point” for further work to reveal the biological underpinnings of depression, which in turn can guide development of new drugs, said Ashley Winslow, an author of a paper on the work.


Dr. Barry Sears Dr. Sears Comments:

Both CBT and BA are watered-down derivatives of ancient Stoic philosophy.  I personally feel that these approaches coupled with an anti-inflammatory diet and high-dose fish oil are a far more effective treatment and considerably less expensive.

A New Depression Treatment Shows Promise

One of the worst things about clinical depression is its cruel circularity. Feeling lousy smothers motivation; loss of motivation leads to inactivity; inactivity makes depression worse-and on and on.




Dr. Barry Sears Dr. Sears Comments:

Of the four supplements, it is the omega-3 (and especially the EPA) that is the most effective at therapeutic doses.  The reason that EPA is more effective than DHA is that it is more effectively transformed into resolvins in the brain and that resolves the inflammation that causes disruption of neurotransmitter signaling.


The Four Best Supplements for Depression

The American Journal of Psychiatry has just published a meta-analyses of supplements, or nutraceuticals, that, used in adjunction to antidepressants, have evidence of reducing depressive symptoms. The primary positive results were found with SAMe (adenosylmethionine) methylfolate, omega 3 (primarily EPA or ethyl-EPA), and vitamin D.

Dr. Barry Sears Dr. Sears Comments:

I am finding that one of the best ways to turn picky eaters into vegetable- eating machines is to mix Zone pasta into their vegetables, add olive oil and put everything together in a bowl.

Dr. Barry Sears Dr. Sears Comments:

Rather than looking for new drugs to target these proteins, it makes more sense to see if high-dose fish oil, which has been shown to effectively treat both bi-polar and uni-polar depression, also affects the same proteins.  If so, then there is no need to make a new drug.