Dr. Barry Sears Dr. Sears Comments:

The data on statins in primary prevention of heart disease is rather pathetic. It is estimated that 100 people would have to take statins for a lifetime to prevent one heart attack death.  On the other hand, 12% of those same 100 people will have likely developed diabetes by taking statins.  That’s not a good trade-off in my opinion.

Many With Diabetes Missing Out on Statins

2 in 5 middle-aged patients don’t get the cholesterol-cutting drugs, despite recommendations to do so, study finds WebMD News from HealthDay By Dennis Thompson HealthDay Reporter MONDAY, Sept. 12, 2016 (HealthDay News) — Nearly all middle-aged patients with diabetes should be taking cholesterol-lowering statins, but cardiologists fail to prescribe these medications for 2 out of every 5 diabetics in their care, a new study finds.

 

Dr. Barry Sears Dr. Sears Comments:

The fact that sudden cardiac death (this is essentially when you grab your chest and die on the spot or at least within one hour) accounts for 300-400,000 deaths per year, you realize that we really haven’t done much in treating heart disease.  Although this article describes the association of higher levels of thyroid with sudden cardiac death rates, it says nothing about lowering the risk using omega-3 fatty acids.  It is clear from animal models (Billman et al Circulation 1999 99:2452-7) that high-dose fish oil can prevent induced heart failure very effectively.  In clinical trials with low-dose fish oil, there is about a 20% reduction in mortality (Chen et al Cardiovasc Drugs Ther. 2011 25:259-65). Someday, may a brave cardiologist might try high-dose fish oil instead of prescribing more statins.

Thyroid issues linked to cardiac death

The small butterfly-shaped gland in your neck produces the hormones thyroxine and triiodothyronine, which help control many activities in your body, from how quickly you burn calories to how fast your heart beats. However, when the gland is underactive (a condition called hypothyroidism, associated with too little thyroxine) or overactive (a condition called hyperthyroidism, associated with too much thyroxine), it can wreak havoc on your body.

 

Dr. Barry Sears Dr. Sears Comments:

Since psoriasis is driven by an overproduction of pro-inflammatory eicosanoids (i.e. leukotrienes), the linkage of psoriasis to other inflammatory conditions like heart disease is not unexpected.

Psoriasis may carry clogged-arteries risk similar to that with diabetes

(Reuters Health) – People with psoriasis may be at increased risk of calcium buildup in the arteries – an indicator of heart disease risk – comparable to that of people with diabetes, according to a new study.

 

Dr. Barry Sears Dr. Sears Comments:

Sitting for no more than 15 to 20 minutes at a time and then walking around the room for 2 minutes is the one exercise that has the greatest return on time investment. Usually it takes 1 hour of vigorous exercise to overcome 8 hours of sitting.

 

Report: Sit less to stave off heart disease

Sitting and other sedentary behaviors are so hazardous to health that adults should significantly limit the time they are inactive to stave off heart disease and stroke, a special American Heart Association panel said in a report published Monday.

 

 

Dr. Barry Sears Dr. Sears Comments:

Gestational diabetes causes genetic programming changes in the fetus that ensure later-life metabolic problems, including obesity and diabetes, in addition to increased risk of heart disease.

 

Dr. Barry Sears Dr. Sears Comments:

This is probably true since their replacements (interesterifed fats) are 20% more effective than trans fats in increasing insulin levels.  Elevated insulin levels are one of the best predictors of future heart disease.  Sometimes the “cure” is worse than the “disease”.

Dr. Barry Sears Dr. Sears Comments:

Aspirin reduces the levels of PGE2 that is an important driver in both heart attacks and colon cancer.  High-dose fish oil also reduces PGE2.

Dr. Barry Sears Dr. Sears Comments:

Poor-quality sleep can generate insulin resistance (an underlying cause of heart disease) within a few days.  Constant poor-quality sleep increases inflammation that drives the acceleration of heart disease.

 

 

Dr. Barry Sears Dr. Sears Comments:

Of course, after all these years no one still has a valid theory to explain the negative impact of trans fats at the molecular level.  I believe that trans fatty acids increase endotoxemia (increased entry of bacteria, especially gram-negative bacteria into the blood) by enhancing the permeability of the gut wall.  Any high-fat diet does this, and I believe that trans fats may be the most effective type of fat in this regard.  By reducing trans fats, you will decrease leaky gut syndrome, and in the process you reduce endotoxemia-induced inflammation that leads to stroke and heart disease.

Dr. Barry Sears Dr. Sears Comments:

Not surprisingly the states with the highest percentage of “old hearts” are those with the highest percentage of obesity.  Both are inflammatory conditions.  Both are best treated by either using anti-inflammatory diets or dramatically increasing health-care costs for the damage caused by the ongoing inflammation.