Dr. Barry Sears Dr. Sears Comments:

Too bad the researchers didn’t go back in the literature to find previous research articles that indicated omega-3 fatty acids also reduce α-synuclein (Kitajka et al PNAS 101: 10931 (2004)). Taking fish oil seems a lot safer than using a cancer drug.

New Protein Discovery Could Mean New Treatment For Parkinson’s Disease

First Posted: Jun 29, 2016 08:59 AM EDT Researchers have revealed that inhibiting the activity of a particular protein in the brain could stop or slow down the development of Parkinson’s disease. So, it may be safe to say that new treatments for the disease are underway.

 

 

Dr. Barry Sears Dr. Sears Comments:

As sad as Parkinson’s is, the article sounds more like a press release for experimental drugs.  Too bad the author didn’t do a review of published articles in the animal models that indicate the role of resolvins in the treatment of Parkinson’s (Tian et al Biochem Biophys Res Commun 460:799 (2015)) or the role of preventing long-term omega-3 deficiencies (Cardoso et al Biochim Biophys Acta 1840:1902 (2014) in the prevention of Parkinson’s.  Taking high-dose fish oil seems a lot safer than being a human guinea pig for the biotechnology industry.

Dr. Barry Sears Dr. Sears Comments:

The growing over-emphasis on genetic testing often drowns out truly unique markers (like sense of smell). Nonetheless, there still remains no treatment for Parkinson’s even through it is known to be an inflammatory condition.  I would take a wild guess that increasing omega-3 intake at the earliest sign of Parkinson’s would have significant benefits.

 

Dr. Barry Sears Dr. Sears Comments:

A very interesting article since Parkinson’s is a neuroinflammatory condition, and this would suggest that inflammation may be first appearing in the intestine and then working its way to the brain.

 

Dr. Barry Sears Dr. Sears Comments:

Since both cancer and neurological disorders like Parkinson’s are driven by excess inflammation, the linkage between the two should not be surprising.

 

Dr. Barry Sears Dr. Sears Comments:

More than half the dopamine in the body is made in the gut by bacteria.  Getting a better microbial balance in the gut may be more useful than a new drug-delivery system for dopamine.

 

Dr. Barry Sears Dr. Sears Comments:

One of the benefits of high-dose fish oil for Parkinson’s patients is its ability to increase dopamine levels.

 

Dr. Barry Sears Dr. Sears Comments:

Reducing the AA/EPA ratio in the blood will reduce neuroinflammation. For Parkinson’s, an ounce of prevention is worth a pound of “cure”.

Dr. Barry Sears Dr. Sears Comments:

The most common feature among Alzheimer’s, Parkinson’s, and ALS is increased neuroinflammation. Thus reducing neuroinflammation should be a more productive area to explore, especially since high-dose omega-3s are very effective in reducing such neuroinflammation.

Dr. Barry Sears Dr. Sears Comments:

Interesting science, but little practical application.