Dr. Barry Sears Dr. Sears Comments:

The problem with resveratrol is that it is very water insoluble, meaning very little gets into the blood even at 4 grams per day.  On the other hand, maqui polyphenol extracts are much more water-soluble; and therefore, more get into the blood and ultimately into the brain. However, polyphenols will not resolve neuroinflammation that characterizes Alzheimer’s, but high-dose omega-3 fatty acids will.  I believe the drug of the future for treating and preventing Alzheimer’s will be a combination of high-dose omega-3s and high-dose maqui polyphenols.

Dr. Barry Sears Dr. Sears Comments:

The caffeine in coffee is the world’s most widely used psychoactive drug.  It is also the primary source of polyphenols for most Americans (since we eat pathetic amounts of vegetables and fruits).  But is also addictive.  Ask any heavy coffee drinker who goes cold turkey.

 

Dr. Barry Sears Dr. Sears Comments:

The only problem with cocoa polyphenols is that they are rich in cadmium and lead.  However cocoa polyphenol extracts can overcome both problems.  We have developed such a cocoa polyphenol extract that has GRAS status, meaning it can be incorporated into food products as you have to deliver about 2 grams of cocoa polyphenols to get the cognitive benefits.

 

 

Dr. Barry Sears Dr. Sears Comments:

Vitamin E at low concentrations is a good anti-oxidant.  At high concentrations, it becomes a pro-oxidant.  On the other hand, polyphenols appear to be powerful anti-oxidants at all concentrations.  This is why longevity increases with greater polyphenol consumption.

 

Dr. Barry Sears Dr. Sears Comments:

The emphasis on probiotics is unjustified since polyphenols can be a more powerful modulator of gut health than probiotics.  There are more than 1,500 different bacterial strains in your gut, and most of them can’t be cultured since they are anaerobes (can’t exist in the presence of oxygen).  It is much more compelling to supply the “fertilizer” (i.e. probiotics) and add the “gardeners” (i.e. polyphenols) to cultivate the complex garden in our gut.  Only then can you add a few “flowers” (i.e., probiotics) to complete the garden.

 

 

Dr. Barry Sears Dr. Sears Comments:

I would just stick with green tea, which is rich in polyphenols and low in caffeine.

 

Dr. Barry Sears Dr. Sears Comments:

It’s the polyphenols in coffee that provide the health benefits.  Although coffee is the primary source of polyphenols for Americans, it is less than the optimal levels for maximum health.

 

 

Dr. Barry Sears Dr. Sears Comments:

A quick science tip:  it’s not the Vitamin C, but polyphenols.

 

Dr. Barry Sears Dr. Sears Comments:

The molecular mode of action of all polyphenols is to increase AMP kinase activity through the interaction with the SIRT-1 gene.  Polyphenols can also activate PPAR gamma.  However, maqui polyphenols are about 400 times more potent than resveratrol because they are twice as active in activating both SIRT-1 and PPAR gamma and 200 times more water-soluble so that they can enter the bloodstream more readily.