Dr. Barry Sears Dr. Sears Comments:

This is probably true since their replacements (interesterifed fats) are 20% more effective than trans fats in increasing insulin levels.  Elevated insulin levels are one of the best predictors of future heart disease.  Sometimes the “cure” is worse than the “disease”.

Dr. Barry Sears Dr. Sears Comments:

Of course, after all these years no one still has a valid theory to explain the negative impact of trans fats at the molecular level.  I believe that trans fatty acids increase endotoxemia (increased entry of bacteria, especially gram-negative bacteria into the blood) by enhancing the permeability of the gut wall.  Any high-fat diet does this, and I believe that trans fats may be the most effective type of fat in this regard.  By reducing trans fats, you will decrease leaky gut syndrome, and in the process you reduce endotoxemia-induced inflammation that leads to stroke and heart disease.

Dr. Barry Sears Dr. Sears Comments:

It is amazing with all the observational studies on the adverse effects of trans fatty acids that there is little knowledge of any potential molecular mechanisms behind their numerous biological effects.