Dr. Barry Sears Dr. Sears Comments:

Cholorgenic acid is a polyphenol that is abundant in coffee.  The amount of coffee you have to drink to get the same levels of cholorogenic acid is massive.  It probably works by activating AMP kinase production that is the genetic master switch that controls metabolism.  The more water-soluble the polyphenol, the less you have to take to stimulate AMP kinase production.  Purified polyphenol extracts from the maqui berry appear to be the most water-soluble polyphenols known.