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The Four Best Supplements for Depression

The American Journal of Psychiatry has just published a meta-analyses of supplements, or nutraceuticals, that, used in adjunction to antidepressants, have evidence of reducing depressive symptoms. The primary positive results were found with SAMe (adenosylmethionine) methylfolate, omega 3 (primarily EPA or ethyl-EPA), and vitamin D.

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Dr. Sears Comments:

Dr. Barry Sears

Of the four supplements, it is the omega-3 (and especially the EPA) that is the most effective at therapeutic doses.  The reason that EPA is more effective than DHA is that it is more effectively transformed into resolvins in the brain and that resolves the inflammation that causes disruption of neurotransmitter signaling.


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