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Gut Denervation Occurs Sequentially in Parkinson’s

SAN DIEGO - The sequence of denervation of gut organs may reflect the stage of Parkinson's disease (PD), a study suggests. When Danish researchers used 11C-donepezil as a biomarker in positron emission tomography (PET) to look at parasympathetic innervation, they found decreased binding in the small intestine, indicating denervation, but not in the pancreas of newly diagnosed patients with PD in the premotor phase of the disease.

Read the article on Medscape

Dr. Sears Comments:

Dr. Barry Sears

A very interesting article since Parkinson’s is a neuroinflammatory condition, and this would suggest that inflammation may be first appearing in the intestine and then working its way to the brain.


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