Dr. Barry Sears Dr. Sears Comments:

The most consistent way to induce obesity in animal models is a high-saturated-fat diet.  The inflammation starts in the hypothalamus long before any increase occurs in weight gain.  If you want to reduce heart disease and diabetes (both inflammatory diseases), then following an anti-inflammatory diet is your best approach.  Such an anti-inflammatory diet is a non-ketogenic diet with most of the fatty acids coming from monounsaturated fat.