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Mechanism Behind Omega-3 Fatty Acid Benefits

Mice genetically altered to produce their own eicosapentaenoic acid (EPA), an n-3 or omega-3 polyunsaturated fatty acid, were protected against heart disease and had improved cardiac function in a recent study (Endo J et al. J Exp Med. 2014;211[8]:1673-1687). A team led by investigators in Japan...

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Dr. Sears Comments:

Dr. Barry Sears

18-HEPE is the building block for resolvins. You can make adequate levels of 18-HEPE as long as you keep your EPA levels greater than 4% of the total fatty acids in the blood. However, to reach that level of EPA in the blood, you need to take a lot of fish oil, like 5-7.5 grams of EPA and DHA per day. The average American consumes 0.125 grams per day.

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