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Mental health: Depression needs large human-genetics studies

Illustration by Denis Carrier Five decades of work on antidepressant drugs have not made them more likely to lift people out of depression. Medications and psychotherapies help some people with the disease, but fail many others. In a study conducted in real clinical settings, a common antidepressant produced a response in just under half of the participants, and achieved full remission in only 28%.

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Dr. Sears Comments:

Dr. Barry Sears

Frankly, I think genetic studies are a waste of time unless you are also looking at epigenetic markers that change with the environment. Diet is the largest driver of epigenetic changes.

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