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Obesity and Inactivity: Study Uses Mouse Model To Show Why Obese Individuals Have Low Motivation To Move

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Dr. Sears Comments:

Dr. Barry Sears

Obesity starts out with inflammation in the hypothalamus. The dopamine reward systems are nearby in the brain. If you have inflammation in one part of the brain that disturbs hormonal signaling, then that inflammation is likely to spread to nearby sections to also disturb hormonal signaling. In this case, dopamine signaling. This is also why obese subjects are more motivated by images of rich desserts than are normal weight individuals when studied by fMRI.

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