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Obesity and Inactivity: Study Uses Mouse Model To Show Why Obese Individuals Have Low Motivation To Move

A study conducted on mice indicates that excess body weight is not responsible for obese individuals' inactivity, but it could be due to alteration in the dopamine receptors. Often, obese people who are low on activity are motivated to begin exercise plans to improve their health.

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Dr. Sears Comments:

Dr. Barry Sears

Obesity starts out with inflammation in the hypothalamus. The dopamine reward systems are nearby in the brain. If you have inflammation in one part of the brain that disturbs hormonal signaling, then that inflammation is likely to spread to nearby sections to also disturb hormonal signaling. In this case, dopamine signaling. This is also why obese subjects are more motivated by images of rich desserts than are normal weight individuals when studied by fMRI.

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