Dr. Barry Sears Dr. Sears Comments:

This was a double loser of a study.  The first study used 1 gram of EPA and DHA per day and demonstrated no improvement in dry macular degeneration.  I published a study (PharmaNutrition 2:8 (2014)) on the same type of patients but using 5 grams of EPA and DHA and demonstrated highly significant improvements in their vision.  Therefore the first study used a placebo-dose of omega-3 fatty acids.  Using the same patients in the second study, not surprisingly, they again found a placebo effect on cognition. Bottom line, placebo doses generate placebo effects.  It is true for drugs as well as omega-3 fatty acids.