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Praluent Looks Cheap to Those With Extreme Cholesterol

The newly approved cholesterol-lowering drug, Praluent, is powerful almost beyond belief. It can drive levels of LDL cholesterol, the dangerous kind, into the 20s or even the teens, numbers almost never before seen in adults. In general, it lowers cholesterol by 50 percent to 70 percent, compared with 25 percent to 55 percent with statins.

Read the article on Nytimes

Dr. Sears Comments:

Dr. Barry Sears

When I was working on heart disease at Boston University, the FH patients were the really interesting ones to work with since you would often see cholesterol deposits on their skin and eyelids.  There is no question for this vey select group of patients that the new drug is very useful.  However, the same FH patients had very low rates of cancer.  I suspect when this drug gets wider population use  in patients other than those with FH, LDL will drop but there will be a significant increase in cancer after five years of use.



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