Dr. Barry Sears Dr. Sears Comments:

Of course, after all these years no one still has a valid theory to explain the negative impact of trans fats at the molecular level.  I believe that trans fatty acids increase endotoxemia (increased entry of bacteria, especially gram-negative bacteria into the blood) by enhancing the permeability of the gut wall.  Any high-fat diet does this, and I believe that trans fats may be the most effective type of fat in this regard.  By reducing trans fats, you will decrease leaky gut syndrome, and in the process you reduce endotoxemia-induced inflammation that leads to stroke and heart disease.