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Unsaturated Fatty Acid Diet Reverses Insulin Resistance in Mice

Studies in mice may help explain the mechanism behind the anti-inflammatory effects of dietary omega-3 and omega-9 fatty acids that help protect against obesity and metabolic disease. The studies suggest that two G protein-coupled receptors -- GPR120 and GPR40 -- play critical roles, "as mediators of the beneficial effects of dietary unsaturated fatty acids in the context of obesity-induced insulin resistance," the researchers wrote online in the journal Endocrinology .

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Dr. Sears Comments:

Dr. Barry Sears

The GPR120 is the primary receptor involved in reducing insulin resistance.  The most powerful activators of this receptor are EPA and DHA.  The GPR40 receptor does not reduce inflammation nearly as much.  That’s why it is a minor role-player in insulin resistance.

 

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