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The weirder side of obesity: genetic forms of obesity are rare yet numerous

The Canadian researchers have identified and cataloged 79 rare genetic syndromes where obesity is a key symptom. A body mass index of 30 or higher is considered obese, where weight is higher than what is considered healthy for a given height.

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Dr. Sears Comments:

Dr. Barry Sears
Although it is possible to obtain insights on obesity in general from the study of rare genetic conditions, the real causes seems always to come back to inflammation disturbing the intricate control networks of the energy balance system and storage of fats.  For example, leptin resistance, a major factor in weight regain, is ultimately caused by increased inflammation in the hypothalamus.  Reduce inflammation in key target tissues, obesity will often rectify itself.

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