Saturday, March 20, 2010

Fish oil, arrhythmias, and death

Last Updated Aug 2007



There has been a flurry of interest in a recent report in JAMA that has linked increased arrhythmias in people who have implanted cardioconverters -- defibrillators (ICDs) -- who are taking fish oil. The prescription drugs used to treat arrhythmias often cause as many drug-induced deaths as they prevent due to the increased arrhythmias they produce. As a result, there has been a surge in the number of ICDs that are surgically implanted. These devices do reduce the mortality rate in patients from about 25 percent per year to about 2 percent per year. But the medical community is always looking for even better ways to reduce mortality, especially sudden cardiac death. For example, in the GISSI study taking only one gram of EPA and DHA reduced total mortality by 10 percent, cardiovascular mortality by 20 percent and sudden cardiac death by 45 percent. It is studies like this that cause fish oil to generate such a great interest in the cardiovascular community for the very simple reason -- you are less likely to die if take fish oil. If the article in JAMA is actually read (which is rarely done by the media), you find a very interesting piece of data: People who took the fish oil instead of the olive oil control had a 60 percent reduction in total mortality. In this study, even though the ICD was activated more often (meaning the patients had more arrhythmias), there was less mortality! How could this be? Obviously, the fish oil was protecting the patients against death as it did in the GISSI study and numerous other studies over the years. Also overlooked by the press in this JAMA study was that 6 percent those taking the olive oil only had to be hospitalized for neurological conditions during the two-year study, whereas ZERO percent of those taking fish oil were hospitalized for neurological conditions. So I guess this is the bottom line from this study: If you want to live longer and not be hospitalized for neurological problems, then take your fish oil
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