Why Do We Get Fat?

The short answer is that we consume more calories than we expend. The underlying reason that happens is because of inflammation in the hypothalamus and other organs of the body that disrupt hormonal signaling patterns. Furthermore, a highly palatable diet rich in saturated fats and glucose will increase the inflammation in all tissues that are responsible for long-term weight control (brain, adipose tissue, liver, and muscles). Increasing the palatability of the diet with sugar and fat will override the intricate energy-balance system in the brain by increasing the hedonic desire for the very food products that induce inflammation in insulin-sensitive organs.