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Alzheimer’s Falls More Heavily On Women Than On Men

For more than 25 years, Mary Read was a successful nurse in Lititz, Pennsylvania. But in 2010, at the age of 50, she started having trouble with her memory and thinking, making it difficult for her to complete routine tasks and follow instructions at work. The problems worsened, bringing her career to an abrupt end.

Read the article on Scientific American Blog Network

Dr. Sears Comments:

Dr. Barry Sears

Those individuals with the ApoE4 genetic phenotype have a difficult time getting EPA and DHA into the brain, meaning less of these omega-3 fatty acids will be in the brain. Regardless of sex, the answer to resolving neuroinflammation in Alzheimer’s is to increase the levels of the hormones (resolvins) necessary for reducing neuroinflammation. That can be achieved by increasing the levels of EPA and DHA in the blood to ensure enough of the substrates are able to enter the brain. This may explain why it was shown more than a decade ago that the AA/EPA ratio in the blood is much lower in Alzheimer patients compared to age-matched controls with normal cognition. It may be likely that women will need higher levels than males to reach that goal. If so, there keep adding EPA and DHA to the diet until the AA/EPA ratio is about 1.5 as it is in Japanese population.


  1. Tamra Roloff

    I am a 73 year old woman. I tend to bruise very easily. I regularly have red or dark marks on my hands and arms. I do take one 81mg asprin daily. I also take approx. 2 Tsp of Fish Oil or Cod Liver Oil daily (Carlson’s Norwegian Fish Oil or Cod Liver Oil). I am often concerned about my memory. Should I make any changes?

    • Maria Gordon

      I would suggest comparing the Carlson’s product to OmegaRx 2 using our fish oil purity calculator. I would think about decreasing the aspirin and increasing the fish oil to get to an AA/EPA ratio between 1.5 and 3.


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