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Rethinking Serotonin’s Role in Clinical Depression.

There's no denying that depression is a form of mental-health epidemic in America. An estimated 17.5 million Americans suffer from some form of depression, with approximately 9.2 million of those cases classified as major or clinical depression. But what is depression exactly? What causes it? And, more importantly, how do we fix it?

Read the article on HuffPost

Dr. Sears Comments:

Dr. Barry Sears

Very striking evidence that serotonin may be the cause of depression. A more likely candidate is inflammation disrupting the communication of neurotransmitters into the interior of the neuron. This is why high-dose fish oil is effective in treating depression.


  1. Marci Corson

    I feel happy and healthy on The Zone since 1997. Only take one fish oil capsule daily and find it supplements my nutritionals perfectly. Why wait for depression?
    Prevention is the key. Was investigating this topic as Kelly Brogan, MD., has been poo pooing serotonin levels causing depression. She may like to review your work to hear your theory on inflammation.


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