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The weirder side of obesity: genetic forms of obesity are rare yet numerous

Scientists identified 79 rare genetic syndromes that cause obesity in addition to mental disability and other abnormal features.

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Dr. Sears Comments:

Dr. Barry Sears
Although it is possible to obtain insights on obesity in general from the study of rare genetic conditions, the real causes seems always to come back to inflammation disturbing the intricate control networks of the energy balance system and storage of fats.  For example, leptin resistance, a major factor in weight regain, is ultimately caused by increased inflammation in the hypothalamus.  Reduce inflammation in key target tissues, obesity will often rectify itself.

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